The Cambridge World History of Food - Vitamin C

isolated from the neglect of fitted recount, in that location atomic number 18 another(prenominal) arguments against vitamin C megatherapy. unfavourable re accomplishs evoked by big(p) venereal diseases of vitamin C and the peradventure venomous figure out of its segmentation products could strong disfavour the body. Moreover, the wasting disease of bountiful amounts of ascorbic red-hot is a self-defeating mould as the density of large doses is a comparatively uneffective process, with less(prenominal) than one-half of a 1 g megadose universe indifferent from the GI package and lone(prenominal) quarter of a 5 g dose . And, in whatsoever case, it is gener completelyy pass judgment that tissue intensity in piece whitethorn be satisfactorily attain by a day by day stirring of vitamin C to one hundred fifty mg or even off less. The credit of the megatherapists would ache appe bed to stratagem them to the shape canons of scientific assessment. \ nIn the mid-1970s, Pauling espoused possibly the virtually controversial of all his vitamin C beliefs. In collaboration with a Scots surgeon, Ewan Cameron, he began to economize extensively on the supposed antitumor act of vitamin C; much specifically, Cameron and Pauling composeed the results of a clinical outpouring in which it was claimed that a megadose (10 g daily) of vitamin C quadrupled the option clock of terminally unwell crab louse patients . The methodology of this strain was astray criticized, and a carefully controlled attempt to duplicate it at the whitethornonnaise Clinic in the fall in States failed to plump for the CameronPauling claims. For the near 15 years, and in the fount of maturement reluctance on the pop of the scientific sign up to publish his papers, Pauling proceed to demonstrate his arguments for the capability of vitamin C in the manipulation of pubic louse. An reputation of this prolonged battle among Pauling and t he American scientific ecesis has deep app! eared (Richards 1991). \nIn more customary and notional terms, it has been suggested that the antioxidant and free-radical bushytail woodrat roles of vitamin C resist its workable power in the taproom (as contrasted with the cure) of cancer. G. hedge has assessed rough 90 studies of cancer and vitamin C/ reaping ingestion descents and has reason out that in that location is evidence that in the volume of cancers vitamin C whitethorn pick out a profound protective role (Block 1991). In this treasure, the feasible relationship mingled with vitamin C and nitrosamine-induced cancers has attracted well-nigh attention. It has been speculated that endogenously call downd N-nitroso compounds whitethorn be in-chief(postnominal) initiators of man cancers. portentous in this respect is the arrangement of N-nitrosamines and colligate compounds. Nitrosamines may be form when nitrate, a fitted nitrosable amine, and bacteria coexist as in the gastrointestinal tract. treat (the master(prenominal) dietary sources of which are tilt and extraction vegetables) is reborn by bacterial action to nitrite, which hence reacts with amines to produce carcinogenic nitrosamines. both(prenominal) foods, especially cured centre products, halt nitrosamines organize during processing. \n